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Re: Amisulpride vs Risperdone vs Geoden

Posted by bleauberry on December 2, 2009, at 5:15:09

In reply to Amisulpride vs Risperdone vs Geoden, posted by ace on December 1, 2009, at 20:34:33

Sorry Ace I haven't tried all these, but I am familiar with Amisulpride and a lot of literature on Risperidone.

In my two-cent opinion, Amisulpride is first choice, at a dose of 25mg. At first it feels activating with the dopamine stimulation, but that quickly adapts into a comfort-zone relaxed confident feeling. Sort of like in the same family as the SSRI emotional bluntness thing, except without the emotional bluntness, if that makes any sense. Just a smooth "everything is ok" feeling, except with an added benefit of interest, motivation, enjoyment of life. It is hard to find cases where Amisulpride actually worsened someone's condition, but I have seen it twice amongst the probably 100 reviews of it I have read, so it can happen.

I would think risperdal would be a good second choice, but at very low doses. I think this one gives a heavy drugged feeling at normal doses. Probably shooting for .25mg - .5 mg, maybe 1mg max?

Geodon, I dunno.

Back to Amisulpride, while its actions on dopamine are fairly well understood, it has recently been found that it also blocks the 5ht7 receptor that may be implicated in some of its work. There are probably other things not yet discovered. Probably the only downside risk with low dose amisulpride is elevated prolactin. Someone else here, and me as well, found that could be avoided with once every other day dosing rather than once a day dosing. But that leaves about half a day of being uncovered.


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