Posted by Sunbath on October 17, 2009, at 6:11:42
In reply to Re: Parnate giving up- Sunbath/ Maxime » Sunbath, posted by delna on October 16, 2009, at 13:04:34
Hi Delna!!! Glad that you are so much better :) !!!!!!!
> I am a million times better- and that is because I never took the Parnate yesterday! I actually have energy today - I slept 5 hours last night but have not needed to sleep at all during the day. It makes me positive when I feel like this.
Absolutely great! And probably it was the Parnate anyway? As you know despite the acute effects its more permanent effects on MAO persist for many many days later..
> But, I know that even though I haven't taken Parnate for 24 hrs +, it has had some effect on my mood which is why today has been ok mood-wise.
> However I still have suicidal thoughts so I know I need to get onto an AD really quick. I'm not sure if Parnate is for me. But I still have a few hours to decide if I am going to take today's dose......Did you take it? Are u planning on switching to daytime dosing before 3pm? Sorry for all those questions :)
> But went to see pdoc today (to find out if I should continue and if so what next)with some interesting developments...
>
> He said to:
> 1) Go up to 60mg (up by 10mg every 3 days). Am on 30 now.That's great! I at least didn't feel any better before I was on 40mg!
> 2) It will take 6-8 weeks to show an effect and I will probably be sedated till then (at least.) Suicidal feelings will be there till then (my parents were not pleased at this thought since he is going off on some conference in the US and there are no hospitals etc)
Hmm please don't think that it must and WILL take you so long.. who knows? Mabye you are already starting feeling good next week!? For me it was all out of a sudden!
Also maybe you're already past the worst part of your sedation? How was it yesterday or today (IF you decided taking your dose)> 3) up the dose of Provigil to 400mg. I explained that this was not the type of sedation that provigil can take care of but he said up it anyway.
> 4)He tried to get me to add low dose Geodon (which has really worked for me in the past but gave me TD symptoms.) I was so annoyed- I mean, why would I need Parnate if I could have Geodon which solves all problems in one go?! I can't take a drug that gives me Tardive pain!
> 5) He pathologized me for knowing anything while he was fumbling with his PDR and on google looking up stuff on Parnate. (BTW I found out that he had only treated a handful of people with Parnate because my mum asked him flat out and he said '5' then quickly changed that to '15' since my mother's jaw dropped)Hahaha, but hey it's better than with my doc.. she has never treated ANY patient with it!
And don't think of it.. I also had so much pdcos who had some kind of "allergy" against me doing my own research or even suggesting something!!That's a big weekness in my opinion! I mean they shouldn't be bothered at all by that.. after all they even should be glad a patient is bringing in some ideas and that he/she isn't only passive!
Well at least that's what I believe!> 6) The worst was that he is not sure that the Parnate will sort out OCD (which I have a very bad case of- currently in remission but will be back as I just gave up my SSRI.)
Hey cool that your OCD isn't back already!Isn't that a good sign? I mean I also have OCD, though lucky me only at a very low level nowadays (obsessive thoughts which were really bad 7-8 years ago). I'm just at my 3rd week of parnate but for me it got rid of the remaining level of OCD COMPLETELY!!! I don't know if it will last, but till now it has had the greatest effect of any med I tried.. also on OCD!
And from my experience as soon as I withdrew from an SSRI my OCD symptoms reappeared very quickly.. is this different for you? Shouldn't your OCD be back already? I ask because maybe Parnate is helping you against your OCD already?> He coolly said ' if Parnate doesn't take care of OCD, we will just withdraw you when it comes back!'.
> I didn't think that was fair since I am apparently supposed to bear 6-8 weeks of feeling like rot just to be (probably) withdrawn again. Parnate has really limited success in OCD apparently from all the info available. But I have posted a message on the board for people's personal experiences which I think will help me make up my mind..That really sounds brutal how he said that, but really you may not have any other chance?But don't worry so much about what might be.. hopefully it will kick in for you really fast from now on!!
Hmm I think there aren't many or even big studies because there's a general lack of studies on Parnate in general, also maybe because it's such an old med.. Did they do much studies in the early 60's about OCD? I have no idea, but I would think probably not.. but if I'm wrong there might have been other reasons why the drug dompany didn't test it for so many conditions.. for example Parnate is really helping me A LOT against social anxiety.. but there haven't been so much studies done about that.. only past 2000 there has been one I think (which was very positive btw).. I often read that much of the evidence of Parnate's effects was from practitioners success with this drug, which may weigh even more than some drug company funded studies I guess.. there are a few case reports where OCD patients remitted on Parnate however..
For me I feel a very strong anti obsessional effect, but I haven't been long enough on Parnate to be able to determine that..> For me, with Parnate the sedation is just too much. I don't think he gets how sleepy I am- I've been sent to sleep clinics before and they said I had idiopathic hypersomnia. That's how I managed to get Provigil in London (where they are also really strict). On top of that is the 'retarded depression' and fatigue. This makes sedation the worst drug side effect for me. I mean, I can put up with alot of side effects but not sedation (though so many people- and u- are saying it will pass)
:( I know you are suffering really much because of this damn sedation! But hey maybe the higher dose will kick in and also make the sedation leave you as it did with me? Maybe it wasn't all coincidence that the sedation finally left me when I increased to 40mg?I dunno...
> I guess the hypotension doesn't come if I take 10mg at once. So breaking up the dose will get rid of that as you guys have suggested, if I stay on Parnate.
Please tell us how that works out for you!
> Am so glad you are sleeping better and having more hours of being alert.
> I hope things keep improving for you....
> Thanks for being so supportive and helpful. It really has helped me.Thanks a lot :) I hope that too.. still afraid it might poop out on me..
You also helped me a lot Delna back when I was so sedated as you are now, thank you!Good luck to you!!! I really hope this damn sedation will leave you out of a sudden and soon as it did with me!
Please keep us updated :)
>
> PS: Here's a (rather negative) article about Parnate and sedation. (I swear, I wasn't looking for bad news- I was just checking on OCD and stumbled on it.)I guess many people have had more positive experiences
> http://www.ncbi.nlm.nih.gov/pubmed/3273886?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumOkay, but the sedation they are talking about is the well known afternoon sleepiness which maybe is different than the sedation you are experiencing now.. I of course don't know, but I think the sedation I had at the beginning was really much different than it is now.. I was sooooo tired the whole day, not just in the afternoon.. now there's still *some* sedation left which feels totally different and which only appears in the afternoon! Also you are taking provigil which should get rid of that remaining sedation.. For example the article in current psychiatry 2002 about parnate in treatment resistent cases talks about the problem of afternoon fatigue and says they prescribe a stimulant to get rid of it like amphetamines, methylphenidate, or modafinil.
poster:Sunbath
thread:920665
URL: http://www.dr-bob.org/babble/20091012/msgs/921224.html