Posted by desolationrower on September 30, 2009, at 0:35:22
In reply to Re: NAC - for akathisia - expansion (long), posted by g_g_g_unit on September 26, 2009, at 4:13:19
hm, i went and looked for anything new. i would say its unclear. i haven't seen much in the way of new research.
using mouse size data, and the pulmonary heart thing study  i estimate 60mg NAC/mouse/day. a 75kg human is 2500x as big, so a daily dose of 150g. mouse metabolism adjustment factor (based on lore) of 6x is 25g/day. which is about 10x as much as a high dose.
but this study indicates some markers of hypoxia occuring at more reasonable doses  although they see it as normalizing things which are going out of line. maybe getting some free-radical generating excercise is important here or something. and normalizing might be also what is going on for someone using it who has symptoms like ocd/schizophrenia/whatever.
ace inhibitors (otc options include pomegranite juice and to a lesser extent tea) stop hypoxia-induced pul.h egcg (green tea) also seems so direclty inhibit the HIFalpha that is downstream of the NO mediated NAC effect and on balance i think it would reduce the risk.  dhea also prevents remodeling, maybe.
NAC has mixed effects on overal cardiac function, see review: maybe something to do with glutathione levels
but this 'replaces the effect of chronic intermittent hypoxia: "CIH decreased the reduced-to-oxidized glutathione ratio and increased the relative amount of PKC isoform- in the particulate fraction; NAC prevented these effects. The expression of PKC- was decreased by CIH and not affected by NAC" i'm not sure whre it fits in.
mortality data shows no change in anything i could find either.
maybe taking an NSAID would mimick the enos negative rats that didn't have the PH response to NAC  However, NSAIds block pgi2 creation(from w-6), and pgi3(from w-3).
mouse info: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1397713
 S-Nitrosothiols signal hypoxia-mimetic vascular pathology
also of interest: http://0-ajpheart.physiology.org.library.pcc.edu/cgi/content/full/294/2/H570
original articles for reference: