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Re: Will MAOIs eventually work AGAIN?

Posted by SLS on September 20, 2009, at 9:15:27

In reply to Re: Will MAOIs eventually work AGAIN? » SLS, posted by Sunbath on September 20, 2009, at 8:20:52

> Hi Scott,
>
> That's very interesting and sounds quite reassuring!
>
> Could you please also tell me when the side effects usually started for you?
> Especially the hypotension and insomnia.. will it begin almost immediately on the very first day (if dose high enough) or does it need time to disable most of the MAO first?

It has been my experience that the hypotension produced by MAOIs is dose-dependent. With Nardil, I begin to experience it at a dosage of 60mg, and there remains some risidual effects despite the passage of time. With Parnate, the dosage is 50mg, and it subsides a great deal over time.

Believe it or not, I don't think it is well understood why MAOIs produce hypotension. There may be some central inhibition of vasomotor centers, but I don't know the specifics. It doesn't appear to be due to peripheral NE alpha-1 blockade.


- Scott

 

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