Posted by iforgotmypassword on August 31, 2009, at 19:03:55
In reply to Re: is desvenlafaxine (Pristiq) still an SRI? » iforgotmypassword, posted by Phillipa on August 31, 2009, at 12:25:07
it's a metabolite, but it is more selective to the NE transporter. i don't know how much SERT affinity relative to NET it has lost, if any, or if it has only lost affinity to DAT.
i want to know how much you can rely on it not being an SRI, similar to how people rely on nortrityline's selectivity, or if i can dream, desipramine's selectivity. certainly its loss of efficacy for major depression according to the always ever sacred HAM-D rating scale suggests it's possible.