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Re: Which drug(s) are best for severe depression?

Posted by trainspotter on August 26, 2009, at 10:51:09

In reply to Re: Which drug(s) are best for severe depression?, posted by SLS on August 23, 2009, at 7:18:33

I am a tricyclic responder true very true, I'll post another thread about anxiety to detail more, the thing about ADs and lifespan has once again become a fight. Forgetting all stuff being professional I think it easier to tolerate 150mg imipramine than 225mg effexor XR. Combinations tried include SSRI + TCA (doubles serum TCA levels) ; Moclobemide + TCA and Selegiline(<10MG) + TCA Alphabetically, Amitriptyline is good , okay great except for huge weight gain (INEVITABLE?) , it's a SEDATIVE, ANXIOLYTIC ANTIDEPRESSIVE. I've done upto 150mg alone and with Paxil20. Desipramine (25-75mg) being NARI combines very well with SSRIs. It's mood elevating energising. Dotheipin is good and Doxepin even at 10mg sedative. Of course I've had a trial of Imipramine, less sedating than amitrip.. NORTRIPTYLINE IS MY SPECIAL GIRL, BEING MORE NORADRENARGIC like desipramine , (25-100mg) it becomes less sedating, hardly any at >75mg. A few beers or St. John's Wort while on it didn't kill me. IT'S FOR DEPRESSION HARD TO LIFT. I read in a journal an article called "Amitriptyline 40 yeras still the best" It's true we are underestimating these drugs with effexor and Cymbalta, TCA UNLESS YOU'RE GROSSLY OBESE CAN BE WAY GOOD.

> You sound like a tricyclic responder. Which ones have you tried so far, and what have you combined them with.

> - Scott




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