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Re: To ColoradoSnowflake and SLS morganator

Posted by SLS on August 24, 2009, at 6:28:07

In reply to To ColoradoSnowflake and SLS, posted by morganator on August 23, 2009, at 23:21:31

> Scott, I am considering dumping Zoloft and starting Parnate 2 weeks later. I am also considering trying Agomelatine. Do you think Ago and Parnate would be a dangerous mix??? I guess I could just go ahead and combine Nortriptyline with Parnate if it helps with sleep.

I am hoping that agomelatine will be safe to mix with MAOIs. I would try it myself. "On paper", I don't see any unsafe pharmacological interactions. However, in real life, who knows? We don't know everthing about these drugs. Does the stimulation of melatonin receptors cause a release of serotonin downstream? I don't know.

> Scott, I know I have asked this question recently so please try not to be annoyed. Do you know of anyone that only doses Parnate one time in the morning? I'm sorry I should have read through the archives. Honestly I'm just being lazy.

I know the feeling. No problem.

I do not believe that once a day dosing of Parnate is sufficient to maintain a steady inhibition of MAO. Whenever I have tried it, I experienced REM rebound at night. REM rebound and vivid dreaming are reliable indexes of a loss of MAO inhibition. I take 40mg in the morning and 40mg at 2:00pm. I think this is an optimal schedule.

- Scott




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