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Re: akathisia and benadryl emmanuel98

Posted by yxibow on August 24, 2009, at 0:10:53

In reply to akathisia and benadryl, posted by emmanuel98 on August 23, 2009, at 19:27:57

> I am taking trilafon and have developed a little akathisia. It's not too bad. I just can't sit still without feeling like I'm going to jump out of my skin. The pdoc at the day program I attend said to take benadryl, which helped. But the web says don't mix benadryl with MAOIs (I also take parnate).

Yes, anticholinergic (atropine like) side effects can be intensified.

Your doctor may be one who believes that there is a serious interaction with MAOIs (it is noted on the packaging, I believe). This may or may not be true with some people.

But I haven't seen any articles noting the seriousness other than common sense of monitoring signs of increased blurriness, dry mouth, psychosis like syndromes which can be a sign of central anticholinergic syndrome.

Artane would probably be less of a sledgehammer than Benadryl, but I can't say for sure.

But if you want to avoid all of this, one main drug of choice for akathisia is propranolol, a non cardioselective beta blocker which has little interaction with what you're taking and is commonly used.

And while one should watch for low blood pressure, all the unpleasantries of anticholinergics can be avoided.

Of course then there is the issue that doctors may take into case that propranolol can cause depression (in some people), but that also isn't always the case and the dose used should be as low as possible.

-- Jay




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