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Re: Did I Give Parnate Enough Time?

Posted by doxogenic boy on August 22, 2009, at 18:54:24

In reply to Re: Did I Give Parnate Enough Time? bulldog2, posted by SLS on August 22, 2009, at 18:11:18

> nortriptyline 150mg

I tried 150 mg nortriptyline against depression in 2001. Then I took a blood test, which showed that I was three times above the therapeutic window. (I am a slow metabolizer, lacking CYP2D6). I had to go down to 50 mg to come into the therapeutic window, and then I felt better, but it didn't work sufficiently against generalized anxiety disorder.

Nortriptyline works best within its pharmaceutical window.

"Numerous articles in the literature have suggested a narrow therapeutic window for this drug. Blood concentrations above or below that window correlate with poor clinical response. Mayo Clinic's experience suggests that relief from endogenous depression can be anticipated in 80% of the patients with blood concentrations within the therapeutic range.

Nortriptyline is administered at a dose of 25 mg 3 times a day to yield optimal blood levels of 50 ng/mL to 150 ng/mL.[...]"





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