Psycho-Babble Medication | about biological treatments | Framed
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Re: Healthier Long Term-MAOIs or SSRIs???

Posted by SLS on August 22, 2009, at 8:40:49

In reply to Re: Healthier Long Term-MAOIs or SSRIs???, posted by SLS on August 22, 2009, at 7:23:44

> There are some studies pointing to elevated serotonin levels increasing mitochondrial damage and apoptosis, particularly with fluoxetine (Prozac). Damage to cardiac endothelial cells has been seen in people who possess the SS gene variant (allele) of the serotonin transporter.

I should note that there aren't more than a handful of studies dedicated to examining these things, and that more intensive investigations are required to corroborate them and to establish firm associations and elucidate the mechanisms that might be responsible for these observations.

I would still not hesitate to use an SRI if it were the only drug that I would respond to. If it comes down to it, I would mix Pristiq with nortriptyline.

- Scott




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