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Re: agomelatine at 1 week, give up at what point?

Posted by iforgotmypassword on August 21, 2009, at 14:28:46

In reply to Re: agomelatine at 1 week, give up at what point? iforgotmypassword, posted by Sigismund on August 21, 2009, at 1:09:27

> Let's see
> >I am anhedonic
> What helps with anhedonia?

for me buspirone after liver enzyme knockout by nefazodone. want to find a safe way to replicate this. hence my focus on serotonin.

> >can't focus or remember anything that I'm doing.
> Can't see how it will help with that.

i see this as a PFC/mesocortical-pathway issue in my case, the nature of my problems and my long lasting tardive movement issues seem to point here (i can go into detail, but i'll be brief, they were SSRI induced, theorised to be related to choking VTA dopaminergic projections through te mesocortical pathway to the PFC).

> >Akathitic. Cannot stop moving/talking purposelessly.
> Might, but I can't see how.

5-HT2c has been mentioned as being of possibly special relevance when it comes to akathisia, including aripiprazole akathisia (5-HT2c partial agonism). i'm under the impression mCPP can be especially unfun and reported to cause akathitic dysphoria in a significant number of people.

> >Brooding on negative, cannot let go of negative, cannot respond to any positive, or see anything that inspires me.
> I should be able to say something useful here.
> >Emotionally cannot handle much.
> My first reaction to agomelatine (noticed by others) was that I was calmer and more self posessed.

i definitely need this. no response yet. my buspirone response gave me a feeling of how livable, calm, and under my control things could be.

> >Annoying to be around.
> Yeah, right.
> >Obviously won't be taking any classes this semestre.
> Hmmmm.
> The drug worked in 2 phases. from the beginning the calmness started along with the sleep improvement.

day 8, still no such response. i think i may have responded when i took a double dose one night.

> After week 2 something else started which I had some difficulties with. Basically a stimulating feeling, noticeable as anxiety in the afternoon. This isn't what you are talking about, IMO. I'm a pretty anxious type, which might explain why I liked it from the start.

this makes me worry a lot. especially since this effect seems to be invoking movement related terminology (RLS), and i found it very confusing. my impression was that 5-ht2c antagonism would be anxiolytic, and very pro-healthy-movement-states. i though 5-ht2c inverse agonism was being eyed for antiparkinsonian potential...

i want tandospirone.




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