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Re: My history with MAOI's SLS

Posted by AdamCanada2 on August 20, 2009, at 15:50:38

In reply to Re: My history with MAOI's AdamCanada2, posted by SLS on August 20, 2009, at 15:38:44

I tried countless things to help Parnate insomnia. Nothing helped and even AP's would not do the trick and instead cause much daytime sedation yet despite sedation not allow me to sleep any better.

I was on 30mg parnate for 2 weeks. The horrible depressed effect remained.

Also I do not feel it is improbable for people to have a therapeutic effect on 10-25mg of Parnate. Not all of us need mega doses. I am sensitive to meds and Paxil 10mg was the ideal dosage for me on such an SSRI while many thought it had to be higher. 20mg on that med (for 2 month I may add) put me in constant sleep. I failed a semester.

Too high a dose is not always a solution for me.

> I can't know for sure, but the things you experienced immediately upon raising the dosage of Parnate from 20mg to 30mg might have been a temporary effect. At 20mg, I doubt you had any significant MAO inhibition. It is likely you were feeling the amphetamine-like effects that the Parnate molecule possesses. Once you reached 30mg, you might have had some inhibition, but not enough to produce an improvement. Instead, you found yourself in an "in-between" state that produced the fatigue and dysphoria. Most people do not respond well to Parnate until the dosage reaches the range of 40-80mg. Feeling "weird" at 30mg might have been a good sign. At 40mg, I would think that insomnia would return. I think that it is unproductive to give up on a drug because of insomnia without first trying to treat the insomnia aggressively.
> - Scott




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