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Re: 5mg Selegiline/Ensam too much/little?? Oral

Posted by Brainbeard on August 18, 2009, at 4:12:23

In reply to 5mg Selegiline/Ensam too much/little?? Oral, posted by AdamCanada2 on August 15, 2009, at 11:01:15

At doses of 2.5mg and below, selegiline is acting more as a catecholamine (dopamine, noradrenaline) transmission booster than as a MAO-B inhibitor. (I'm sorry, I'm too lazy to give any references. If somebody kicks my *ss for it I may (gruntingly) look them up for y'all.) Many people seem to use selegiline in these low doses. Some people even use such a dose a couple of times a week instead of every day, believing it prevents dopaminergic brain aging.

My personal experience is that 2.5mg only makes me feel a little uptight without giving me much benefit - unless I combine it with tianeptine (best results with 25mg at once), in which case I get a very nice synergistic effect (both stimulating and mellowing).

So I would certainly give 2.5mg or even less a shot. It's worth trying. Don't expect it to save your life though. It's probably way too mild for that.




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