Posted by doxogenic boy on August 15, 2009, at 9:08:10
Hello to all of you.
I have treatment-resistant depression, obsessive-compulsive disorder, generalized anxiety disorder and social phobia, which I have had most of my life. A problem that is part of this, did I mention in the newbie group (things take long time for me to do because it has to be so circumstantial).
My current combination is:
quetiapine 600 mg (200 + 100 + 100 + 200 mg)
liothyronine sodium 20 mcg (20 mcg in the morning)
escitalopram 40 mg (40 mg in the morning)
tianeptine 150 mg (4 tablets 12,5 mg three times a day)
clonazepam 1 mg (1 mg at bedtime)
trimipramine 100 mg (100 mg in the evening)
Friday 8/7/09 hydromorphone immediate release 3,9 mg (1,3 mg three times a day) was added and Thursday 08/13/09 I started with 4 mg sustained release capsules, Friday 08/14/09 4 mg twice a day.
I think all of the medicines contribute to the antidepressant effect, and most of them also to the anxiolytic effect, because I experienced an improvement when each of them was added, but it was the hydromorphone that gave it the finishing touch.
This is the 9th day with the hydromorphone combination. I have not felt any euphoria, but I feel calm and a little more confident. My worries are there, but they just pass away without scaring me. Usually, I am insecure and anxious.
What I would like to get advice about, is what I can do if I experience tolerance for, or loss of effect of the hydromorphone. It has been nasty when I have had a hope to a medication to get me into remission, when it stops working.
And I wonder how the SSRI/SSRE combination works, as they theoretically should cancel each other out? What about hydromorphone/tianeptine, could there be a synergetic anxiolytic effect?
(I get all of the medication on prescription, and I ask my psychiatrist if I will change anything).
I want to write much more about this, but I think it is time to post, to get started. :)