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Re: Jay, Doexipin? qbsbrown

Posted by yxibow on August 12, 2009, at 6:12:37

In reply to Jay, Doexipin?, posted by qbsbrown on August 11, 2009, at 21:51:55

> Well, it's kinda strange. I can tell how a med is going to act the whole time from the get go, and I typically feel it's whole effects from day 1. but yes, it is worth a try. Having to take the generic every 4 hours is a pain in the butt.
> Well, this is my last taper of diazepam (5th attempt), and has been my most difficult. I hope that with carbamazipine on board, it think it will help, as many studies have shown.

I'm not sure why all the medications are necessary to taper off of a benzodiazepine, I mean I can understand the "reverse anxiety" that comes with it, but that is a natural part of coming off one, I can tell you it can become worse with intense GI/bowel effects.

The benzodiazepine will always be there around for you if you have to go back, why make an agonizing taper, just take it easy at the standard care of about 10% a week, more if you can, less if you can't.

> Secondly. Dr. Heather Ashton mentions Doexepin being used for benzo wd for anxiety and sleep.

I'm not going to comment on "Ashton" methods... I believe it is a scope outside of evidence based psychiatry and demonizes even proper use of benzodiazepines...

> Ironically, after waking up at 3am last night after horrible brutal sleep (which is more common now), I took a benadryl. Although it did not allow me to sleep, but gave me relaxation that i haven't experienced during this whole taper in the past 5 months.

So would Atarax... some antihistamines also act for some people as calming agents; but they can cause blurry vision, tachychardia, etc. Thorazine came from a particular class of antihistamines

> I took 2 more doses of benadryl during the day today, and it has been the most relaxing day thus far, hands down.

Glad to hear that... I'd have a hangover and blurred vision, but everyone is different.

> So i think there is something there to histamine for me. I don't do very well with anything serotonin based, as it usually induces a feeling of depression, or even sometimes even mania/hypomania.

Well, even some antihistamines act barely on serotonin, such as chlorpheniramine.

> I see that doexepin is a great histamine blocker. Do you think that that is something worth looking into and talking to my dr about?

For people with bad allergies, it is one of the only drugs with antihistamine properties that blocks both H1 and H2, small doses would only be needed

Otherwise... its an antidepressant in any useful dose, so I don't see the purpose of using it otherwise... and it does act on serotonin more than NE, as well as being a fairly strong antihistamine.

> Is it ok to mix a tca w/ tegretol?

Most likely.. I'd still go with Trileptal personally as being more safe and having less side effects since you'd be mixing TCAs which have their own side effects, but you respond better to Tegretol.

-- Jay




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