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Re: Wellbutrin for sexual side effects?

Posted by SLS on July 30, 2009, at 16:10:38

In reply to Re: Wellbutrin for sexual side effects?, posted by Zana on July 30, 2009, at 15:21:37

Sexual function is dependent upon a delicate balance of the stimulation of the various serotonin receptors.

Risperdal blocks 5-HT2c receptors, the result of which is a reduction in erections and probably libido too. Interestingly, the overstimulation of these receptors might reduce libido. Seroquel can actually increase libido in some people by acting as an antagonist of 5-HT7 receptors. Buspirone should produce somewhat more libido and make it easier to reach orgasm by acting as a 5-HT1a agonist. However, it is harder to get an erection in the first place.

Most of this information comes from rat studies, so the dynamics in man might be somewhat different. For example, blocking the 5-HT2a receptors in rats reduces libido significantly. In man, it does not seem to have this effect. The dynamics of sexual function are very complex and involve many receptors and diverse areas of the brain.


- Scott

 

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