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Re: Intrusive OCD thoughts?

Posted by Brainbeard on July 18, 2009, at 7:55:45

In reply to Re: Intrusive OCD thoughts? » Brainbeard, posted by SLS on July 18, 2009, at 1:44:10

> Hi Brainbeard.
>
> Which dopaminergic brain regions or tracts does 5-HT3 receptor stimulation activate?
>
> How might memantine work as a treatment for OCD?
>
> Thanks.
>
>
> - Scott

OMG.. An assignment! Gimme some time, Scott... Just gimme some time..
I think it was the mesolimbic region..

..........

'In this brief review, we present the evidence for the regulation of the mesolimbic dopamine system by 5-HT3 and 5-HT4 receptors. A range of studies show good evidence that 5-HT3 receptor antagonists reduce raised mesolimbic dopamine activity by blocking 5-HT3 receptors in terminal parts of the mesolimbic dopamine system.'(Behavioural Brain Research
Volume 73, Issues 1-2, 15 December 1995, Pages 11-13)

To be honest, I know almost nothing about the different brain regions and their functions. I think that the mesolimbic region is linked to emotions, amongst other things. Anyone feel free to enlighten me.

[Does some quick googling] No, it is a MEDIATOR between the limbic (emotional) system and other parts of the brain.
Wikipedia: 'It [the mesolimbic pathway] is known to be involved in modulating behavioral responses to stimuli that activate feelings of reward (motivation) and reinforcement through the neurotransmitter dopamine'.

Memantine.. Almost never heard of it.. I saw someone using it a while ago on this forum.. [Does some quick googling] Memantine, my friend, is an N-methyl-D-aspartic acid glutamatergic receptor antagonist. That's right. So, how can it help with OCD? Well, I would say by attenuating glutamatergic hyperactivity (http://ajp.psychiatryonline.org/cgi/content/full/162/11/2191-a).



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