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Re: Best Bipolar II with depression cocktail?

Posted by SLS on July 13, 2009, at 18:00:09

In reply to Re: Best Bipolar II with depression cocktail?, posted by linkadge on July 13, 2009, at 10:05:17

> Seroquel has AD properties. The company was trying to get it approved as a treatment for unipolar depression. Try different doses to see how they affect your mood.

I think this a perfectly reasonable course of action. I am glad to see you acknowledge the possibility that Seroquel is good for something other than flushing down the toilet.

Unfortunately, I did not have much luck with Seroquel. I found that it caused me some dysphoria and irritability. My guess is that it is the NET inhibition produced by Seroquel's metabolite, norquetiapine, that was responsible for this effect. I have not yet seen Seroquel work as an antidepressant at low dosages. My guess is that 150-300mg is a good target range.

I always find Zyprexa to be a life-saver when I really need it. It has saved me from severe suicidal depressions as well as severe delusional manias. For me, it has more mood-brightening properties than Seroquel. Zyprexa would be a great drug were it not for weight gain and its potential to precipitate diabetes. These things are also possible outcomes with Seroquel, but the rate of incidence seems to be lower.

Wellbutrin + Seroquel is working well for a friend of mine who suffers from depression and mixed-states.


- Scott

 

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