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Re: Inositol to augment NRI's » linkadge

Posted by SLS on June 14, 2009, at 9:24:25

In reply to Inositol to augment NRI's, posted by linkadge on June 14, 2009, at 8:03:13

> Apparently inositol has little to no value as an adjunct to refractory SSRI users. Perhaps because both agents are working on the serotonergic system.
>
> I wonder if inositol would be a good adjunct to those who are partially responding to an NRI? In this sense, the NRI and inositol might be activating complimentary neurotransmitter systems.
>
> Anyone tried this? Say inostol plus wellbutrin, nortriptyline or desiprmine?


Those are real good thoughts.

How does inositol become serotonergic in particular? Is it a membrane thing or a second messenger thing? Neither? Calcium channel thing? A quick look at Wikipedia didn't really address this issue, or I must have missed it. One thing for sure, though, is that they reported efficacy for inositol in OCD, which would lead one to believe that serotonin is involved.


- Scott

 

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