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high dose diphenhydramine for tardive syndromes

Posted by iforgotmypassword on May 12, 2009, at 15:16:39

someone detailed a possible treatment for tardive movement syndromes a while back.

this was the 5-day regimen:
1) diphenhydramine (Benadryl) 100mg every 4 hours (this seemed to be mentioned as a 4 times a day thing in another post)
2) quercetin 500mg daily
3) alpha lipoic acid (no dose specified, i have chosen 100mg with each diphenhydramine dose)

(this was one of the posts relating to it.)

the idea was that the 5-day regimen would reset the dysregulated dopaminergic response somehow.

I find it interesting. the concept may interestingly relate to what a nurse said to me once when i was in the hospital, that some people only need cogentin once every several months. that they can take it once and then they're fine for a notably extended period. maybe this concept is an application of this phenomenon, with added power, and maybe more likely to be successful in a wider range of cases.

Also, in india, studies of quercetin, as another antioxidant with some action against tardive movement syndromes have been published, and come up on pubmed.

I have started taking both the quercetin and the ALA.

I will skip to the **main question** now, as someone who is very sensitive to antihistamines, how easy is it to tolerate 100mg of diphenhydramine in one go, and is there any danger associated? The dosage seems to be used/techinically athorized as a maximum, but I am someone who has had bizarre breathing/paralysis problems relating to sleep and fatigue made worse by certain drugs. Should I be concerned? It was not decided what causes this in me. When risperidone made it very prominent in the hospital, I felt very strongly that the tight stops in my breathing were antidopaminergic related, but my doctor thought it was due to the sedative nature of the drug. I still lean toward my opinion, but am worried either way, as it is a very panicked "I think I might die" feeling.

Maybe I should be asking this specifically as well: What doses are common with diphenhydramine when treating movement issues?

(sorry for any disorganization, and the evident lengthliness of this post.)




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