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Re: I'm better (recovered from Tryptophan) now what?

Posted by Tepidarium on May 2, 2009, at 16:02:27

In reply to Re: I'm better (recovered from Tryptophan) now what? » Tepidarium, posted by Larry Hoover on May 1, 2009, at 17:30:11


> I don't recall specifically saying that. Are you referring to this: "First, gut tryprophan hydroxylase activity is regulated by an LDL (low-density lipoprotein) receptor. High activity at that receptor suppresses TRP. I'm not sure that messing around at that level would be clear-cut, as we're still very much in the dark with respect to cholesterol regulation." From: http://www.dr-bob.org/babble/20081204/msgs/866984.html

I was referring to this message you posted:
http://www.dr-bob.org/babble/alter/20081006/msgs/870022.html

The thread you referred to is, I guess, where you were drawing your conclusions.

>
> > I thought taking tryptophan over 5-htp would avoid the problem with serotonin conversion in the gut as opposed to the brain.
>
> It reduces the likelihood, but does not eliminate it.
>
I assume I must be highly sensitive to tryptophan is 2.5 g a day could produce the pupil dilation, eye sensitivity to light, and body aches.

> If you want to maximize brain uptake of tryptophan, you should take it on an empty stomach. Maybe half an hour later, consume something with a high glycemic index, but low protein. This will cause a small insulin spike, which will clear the blood of most aminos, but not tryptophan. That leaves little competition for tryptophan to access the LNAAT (or sometimes called LAT), which transports it across the blood/brain barrier.
>

When I took tryptophan, I always took it on an empty stomach with a little bit of orange juice. At the time, I was not taking a separate b complex vitamin, (but I was taking a multivitamin with b complex) I wonder if the absence of extra b or niacin could have contributed to the problem?

> > I'm thinking about a dosage of 1 500mg capsule a day. Unless I buy powder, I think this is lowest I can dose.
>
> That's a good starting point. I used to use 6 g/day. I understand that your tolerance is less than mine, however.
>

Do you think the symptoms I experienced were indicative of serotonin syndrome? I thought serotonin syndrome meant that there was too much serotonin in the brain, not too much serotonin being converted in the gut...

My doctor poo-pooed my symptoms and didn't think 2.5g of tryptophan could cause serotonin syndrome.

I'd like to try one 500mg capsule again, I'm just a little hesitant.



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URL: http://www.dr-bob.org/babble/20090426/msgs/893901.html