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Re: New version of Nardil » Cseagraves

Posted by SLS on April 12, 2009, at 6:51:25

In reply to New version of Nardil, posted by Cseagraves on April 11, 2009, at 13:32:31

Hi.

You can see that there is much dissension among Nardil users past and present whether or not there is a *clinical* difference between the old versus new Nardil. I made the change from old to new while in the middle of Nardil therapy. I found no difference between the two regarding efficacy or side effects. However, I feel sure that there are people who do better on brand name versus generic preperations for numerous drugs, some of them being psychotropics. In my doctor's experience, the name brand is superior for preparations of paroxetine and lamotrigine to name a few.

Different is different. The "inert" ingredients are different. So might be the manufacturing process. One might expect that some generics have different clinical properties when compared to the name brand. I imagine that some complaints are due to a sort of self-fulfilling placebo-type response to the change.

Anyway, it sounds plausible that the binders and exipients that vary from one preperation to the other produce differences in bioavailability. However, I have absolutely no factual proof of such a thing.

If, after the change from old to new, I began to relapse, I would have petitioned my doctor to simply raise the dosage. It might be simplistic and wishful thinking, but I should hope that others might have tried this with good effect.

Seeing is believing. Not seeing provides a rational tendency to disbelief. The new vs old Nardil debate has become quite passionate. I personally have not seen anyone at PB demonstrate a different clinical response to one prepatation versus the other upon change-over.

Let us keep an open mind, just in case no scientific proof comes our way any time soon.


- Scott

 

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