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Re: MAOI food question » garnet71

Posted by jedi on April 9, 2009, at 2:12:32

In reply to MAOI food question, posted by garnet71 on April 7, 2009, at 18:14:15

> So if certain aged foods cause a strong chemical reaction in the brain while on MAOIs, what does that imply for the effect of those same foods on a person's brain who doesn't take MAOIs?
>
> I mean, its not due to the chemicals in that little pill, right (or is it?), but rather the changes it facilitates in your brain chemistry.
>
> So-wouldn't those same foods cause some subtle reaction to brain chemistry for those who don't take any drugs?

Here is a simplified explanation on how MAO-A in the gut stops the absorbtion of tyramine. The irreversible MAOIs(Nardil, Parnate, Marplan & high dose selegilline) inhibit the MAO-A in the gut thus allowing the tyramine to be easily absorbed into the rest of the body.
Jedi

http://emedicine.medscape.com/article/815695-overview
"MAOs are located in many tissues, including the gut wall. MAOIs absorbed through the gastrointestinal tract bind significantly to MAO in the gut mucosa and liver producing significant first pass effect. To be effective in the CNS, their location of clinically significant effect, they must be given in high enough concentration to reach plasma levels and thus brain levels, sufficient to produce binding centrally to MAO. MAO-A in the gut acts as a barrier to the absorption of tyramine, and thus ingestion of substances containing tyramine may produce significant toxicity."


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