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Re: Nefazodone causing panic attacks? » brooke484

Posted by jrbecker76 on March 24, 2009, at 10:44:38

In reply to Re: Nefazodone causing panic attacks? Help! Myco, posted by brooke484 on March 24, 2009, at 10:06:13

I recommend decreasing the dose (e.g., 150 mg) and going SLOW in titrating up.

I took a low-dose of Nefazodone for years and I found it to be a great augmentor to SSRIs/SNRIs. However, as you point out, it can have some activating side effects in some people. This is due to one of its metabolites -- m-CPP -- which is building up in your system. Every time you increase the dose, you might feel some of these same effects. It will take a few days for your body to adjust. What will happen is that another one of the drug's active metabolites -- hydroxy nefazodone -- will eventually begin to cancel out a lot of the activation problems caused by m-CPP.

So it takes a little patience. I've found that only a small minority of people who wait it out still end up reporting significant activation effects. So once again, my advice to you is to drop the dose until you have adjusted before you begin to titrate up.

http://www.dr-bob.org/babble/20060122/msgs/602044.html

JB


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URL: http://www.dr-bob.org/babble/20090322/msgs/886800.html