Posted by SLS on March 16, 2009, at 20:55:11
In reply to Re: I want to switch from nortriptyline to desipramine » SLS, posted by JadeKelly on March 16, 2009, at 18:50:32
> > I am not experiencing the improvement I expected. Depression is getting worse, not better. I have been on desipramine 300mg for only 12 days, so there is still something to hope for.
> > I might have to go back to nortriptyline.
> > - Scott
> Hey Scott,
> What would the response time be for someone who has never taken Desipramine? Are you still having insomnia?
> Remember, its not over yet. Its going to work and you're disappointed at how long its taking. I waited months, remember? ALL on faith. I still can't believe I made it. And you will too. Sorry but 12 days is a little early to start being negative. Hope it hits soon and complete. Ya just never know.
Hi Grasshopper :-)
I misspoke. It has actually been 21 days that I am at the 300mg dosage. It is still too early to give up on it, though. However, I should see something more substantial soon if my drugs are optimized. I see my doctor tomorrow. I received the results from the blood test for 300mg. It came back at 191. The therapeutic range is between 100 - 300. I decided to take an extra 100mg of desipramine tonight to see if I were somehow just short of my therapeutic dosage. There is certainly enough room in blood levels to do this. I would feel noticeably better tomorrow if this were the case. If there is a night and day difference, I am going to have to explain my actions to my doctor. I'm just going to tell him that I couldn't wait anymore. 3 months of deterioration was enough.
I began to recover later in the day today. It is nothing great, but I feel better than I had been over the last few days.
I have to admit that the last few days have been an emotional roller-coaster ride for me. I had suicidal thoughts creep in when I felt that my drugs had stopped working. I was despondent on top of being depressed. Not a good combination.
Still moving forward...