Posted by bleauberry on February 26, 2009, at 17:40:45
In reply to Re: AD or AP during pregnancy » bleauberry, posted by B2chica on February 26, 2009, at 7:51:46
The link at the end of this post is a detailed study of SAMe in HIV patients with depression. It's weakness is that it was a small trial with no placebo and no comparator drug. However, results were astounding and there are charts from week to week showing the improvement. The overall remission rate in those who finished the study was 93% with scores of less than 7 on the depression test when they had started in the 30's.
It has a lot of detail that is encouraging to get to know a little bit more about SAMe and its functions. It raises hope because it did so well with other people, so why not us?
No one knows exactly how supplementing SAMe heps, just that it does. Fibromyalgia, pain, aggression, depression, fatigue, liver function, joints, detoxing toxins. It is beneficial body-wide.
It can spark mania, though in all the studies I've looked at it didn't appear to have any higher risk at that than any other drug choice.
3 days ago I took 200mg SAMe. That day I felt irritated, agitated, more energy, warmer, less appetite, amazing disappearance of pains, disappearance of cramping leg muscles, no mood boost. Sweet and sour. I woke with a bad headache, kind of out of it, took another 200mg, and about 2 hours into work I realized I was feeling a lot better than I am accustomed to, both physically and emotionally. I think I overdid it, because I konked out at the end of the day similar to an Adderall crash.
Granted, to stick with it, I need to bear with some start-up headache stuff in the morning, maybe a little lessened appetite, and maybe a slight sense of uneasiness at times, and a second dose in the afternoon probably. I do believe those side effects, as with any supplement or drug, would disappear in 1 to 4 weeks. Start-up of anything can be a trying transition period, especially for someone sensitive like me.
I've never had any drug, herb, or supplement, help in so many ways so fast. In the study linked, there was great improvement already at just one week. I felt that. Not just in mind, but body. Pains and cramps gone. Amazing.
As for a baby's safety, I cannot imagine how adding some methyl donors to our bodily functions would hurt, probably only help, and maybe our methylation is already poor to begin with and we are just restoring it to normal which makes a healthier baby?
One thing for sure, depression is harmful to a baby, almost as much as arsenic or mercury. SAMe looks pretty good to me.
You mentioned antipsychotics. If you have any anxiety, paranoia, schizo symptoms to deal with, I do not know how SAMe will help or hurt those, only that in one study aggression in schizophrenic patients was reduced with SAMe.