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Re: Imipramine.. damn hypotension

Posted by SLS on February 23, 2009, at 9:47:03

In reply to Re: Imipramine.. damn hypotension, posted by mav27 on February 23, 2009, at 9:20:19

> Well tonight after upping the dose from 75 to 150mg things actually seem better. I went to sleep for about 2 hours thanks to the anti-histamine stuff but it's now 7 hours later and i dont feel sleepy ( i actually didn't notice when the sleepy feeling went away so i don't know how long it lasted) and my standing blood pressure is 100/80 pulse 120 which is a good improvment.

Very cool.

I am glad you found the secret by yourself.

I was going to suggest increasing the dosage, but I know that would have been counter-intuitive. What you now experience might be due to:

1. The relative contributions of NE alpha-1 receptor antagonism versus NE reuptake inhibition changing as the reuptake inhibition becomes more prominent.

2. A reduction in dysautonomia as the drug begins to exert antidepressant effects. These tend to show up as physiological changes at first, followed by mood improvements. If you have LESS dry mouth, sweating, blurred vision, hypotension, and feel less cold, then the partial resoulution of dysautonomia is a likely explanation.

I think you are on the right track.


- Scott

 

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