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Re: Do dopamine DA receptor agonists really work?

Posted by bleauberry on January 20, 2009, at 18:35:39

In reply to Do dopamine DA receptor agonists really work?, posted by SLS on January 19, 2009, at 20:39:40

Hi Scott. I was scouting all the review-ratings boards a few weeks ago and was looking at what actual users said about the dopamine agonists. Most were pramipexole, but there were a couple others. There were hundreds of reports, roughly about 80% bad ones.

Basically, bromocriptine was worthless amongst pretty much everyone.

Pramipexole was skewed heavily toward the bad experience side of things. It seemed to be good for restless leg syndrome in tiny doses. Other than that, there were nurmerous mentions of things like craziness, OCD-like behavior, complete personality changes, rage, broken marriages, and all sorts of bizarre things. It scored very badly overall. These things all resolved within a few days of stopping the DA agonist.

But if you look at case studies and trials on pubmed, agonists do pretty well. I guess clinical versus realworld are different, maybe in the way participants are selected? But even in the clinical settings that showed promise with pramipexole, I think it was something like a 60% relapse rate within a couple months.


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URL: http://www.dr-bob.org/babble/20090104/msgs/875199.html