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Re: Actually, that's not what the study found.

Posted by linkadge on December 30, 2008, at 20:58:26

In reply to Re: Actually, that's not what the study found. linkadge, posted by Larry Hoover on December 30, 2008, at 17:58:36

Yes, but in spite of the initial state of the partipants, the TCA group still deteriorated faster in terms of white matter. Yes, I suppose that this could be a result of worsening depression. It could also simply be that the TCA was infact producing white matter atrophy.

For a while, enhanced cardiac mortality on TCA's was also blamed on depression. It is now strongly believed that TCA's perpetuate cardiac disease.

I understand that the study may not be conclusive proof of anything, but it is still worth considering the possability. I mean there are a few potential mechanisms by which such such an effect could occur.

I know certain anticonvulsants (ie tegretol) is linked to white/grey matter atrophy as well as cytotoxicity. Many of the SSRI's are cytotoxic as well many increase oxidative stress. The TCA's can definately enhance cortical excitability and glutamatergic output. Some antidepressants, like elavil and fluoxetine directly decrease glutamate reuptake. There was a study which demonstrated how fluvoxamine enhanced glutamate neurotoxicity associated with MSG. Anyhow.





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