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Re: Wellbutrin SL and XL - Use After Bariatric Surgery » SLS

Posted by Vincent_QC on December 26, 2008, at 22:29:23

In reply to Wellbutrin SL and XL - Use After Bariatric Surgery, posted by SLS on December 26, 2008, at 6:30:09

> Hi all.
>
> A friend of mine is having bariatric surgery soon and will be left with a small vestigial stomach.
>
> Someone on the treatment team told her that she could no longer take the sustained release preparations of Wellbutrin. She was told to use the IR immediate-release version only. No explanation was given. I'll need to do some homework for her, I guess. I get the feeling that it is just not necessary to make a switch to the IR.
>
> Does anyone have information on this?
>
> My friend has already made the switch to IR to see if it will sustain her 8-year remission of depression. The answer is no. She began to deteriorate within a week and is not doing too well. I convinced her to return to XL until she has her surgery in a few months. If her physicians are unsure as to the efficacy of sustained release versions of Wellbutrin, but are convinced that it will do her no harm, then it is a no-brainer but to try as an experiment its use.
>
>
>
> - Scott

Hi ;-)
I had a gastric by-pass in 2001...mine work with "malabsorbtion" ...mean that they just remove 2/3 of my stomach and they reduce my intestine to 1 meter long only, the other 5 meter is cut and don't work anymore (we have more than 6 meters I think)...And yeah, I see a difference...I can't take the newer XR version of any drugs...the main problem is that in Canada IR version are often not avaible. Effexor come only in XR version, Wellbutrin come in SR and XR version only...the new cymbalta is a XR version also, Paxil goes XR also, Luvox XR also...

For your friend, I don't know if a small stomach can affect the SR efficacity...??? Since drugs are most of the time absorb into the small intestine, I wonder if the Wellbutrin SR will not be as affective than before your friend got his surgery?

I ask several times my surgeon about this, and about the fact that the new formulation XR of drugs seem to not work on me, since at one point of my life I Was on more than 300mg of Effexor-XR, without feeling anything...it was not normal... The only answer I get was that he don't know...He said that statically, I maybe absorb only 30% of the drug in my blood stream...normal digestion cycle is 12 hours, mine is 3-4 hours...and since I get this surgery, I find that all the drugs are less effective...so it"s affect probably also the regular version as well...since they by-pass the first part of the intestine, the one where the fat absorbtion in the intestine is made, and it's the part where normally a drug is absorbed...but some drugs seem to be well absorb...probably something to do with where a drug is absorb and metabolised...they are all different I think...but my psychiatrist told me that AD drugs are mostly absorb by the first part of the intestine and are fat-solube...mean that i'm not surprise I don't answer well to antidepressants drugs...

Take my informations like you want, maybe i'm right or maybe i'm wrong, but a small stomach can't affect what happen in the intestine...If your friend take her Wellbutrin SR and swallow it, I see why it will not go into her intestine...so it will probably be absorb like usual in the intestine, since her surgery will not by-pass a big part of her intestine no???

Wish her good luck for me ok ;-) By-pass surgery is a very difficult step in the life of someone...and this surgery will make her more happy after and less depressive i'm sure ;-) Loosing weight is always very pleasant.


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poster:Vincent_QC thread:870846
URL: http://www.dr-bob.org/babble/20081223/msgs/870965.html