Posted by desolationrower on December 12, 2008, at 2:22:36
In reply to Re: phasic vs. tonic inhibitory currents/psych med » desolationrower, posted by B2chica on December 11, 2008, at 15:35:06
> well i know that psych meds obviously effect certain neurotransmitter in a manner of agonist, inhibitor, but didn't know if they effect the current as well?
> since GABA is tonic, my theory goes that
> when emotionally normal, normal GABA is tonic, when in a manic phase the current somehow becomes phasic and thats why some meds may not effect mania, because they effect the NT themselves and not the current which in some cases may be the only 'disorder' if you will.
I think they operate on a much more frequent level, every second there is phasic activation of many gabaergic neurones...hm, theres a lot on this, but i think there can be a link, normally when i think of tonic/phasic i think of role in modulating the orchestration of neurones into sysmtes in the brain, and the information processing stuff. i liked maths but reading calculus and statistics is just too much for me to remember. but tied in with bipolar, it could be analogus to epilepsy kindling, at least thats what i think of when i think of improper gaba neurone patterns, the improper synchronizing of neurones in the brain.
> i was also thinking then that 'normal' serotonin levels would be phasic, and when a person becomes depressive the serotonin takes on a tonic attribute. thus why some AD's make you manic, not needing a serotonin LEVEL adjustment, but just need a 'current adjustment'...
i think something like this might be the case with the locus caeruleus and norepinephrine... i think phasic activation is reduced by methylphenidate, so behaviour is less activated, tonic is increased, more attentive to surroundings...
> i'm not saying tonic/phasic across the board mind you. i'm just thinking outloud. and that maybe Some peoples issue may not be the level of neurotransmitter but the current of it.
> and keep in mind i just learned about these tonic/phasic variables in nt today, so i really don't know much about it, thats why the inquiry.
> but i'm very excited to learn more about this...
> thanks for checking on your end too!
good to bring this up, instead of just 'more vs. less' of a transmitter...it all matters, circuits/location, pattern of activation, interplay with immune system, etc.