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Re: serotonin and bone density » fayeroe

Posted by Larry Hoover on December 11, 2008, at 18:38:02

In reply to Re: serotonin and bone density, posted by fayeroe on December 10, 2008, at 20:23:05

> Thanks, Larry for posting all of this information for us.

You're welcome.

> I don't know which would come first for me, the bone problems or the depression. Meaning, what would I sacrifice if I had to make that decision.

There is some association between the use of antidepressants and decreases in bone density, but it's pretty hard to draw a causal link. Depression is itself inversely correlated with bone density. With what I've read with respect to the bone serotonin receptors (there are three identified types, possibility of more), it's quite possible that antidepressants bind to those bone receptors. Binding alone might be meaningless, but we'd have to know more about which antidepressant has affinity for which receptor(s), and whether there was an agonist or antagonist effect. It could be crazy-making, trying to analyze it all.

Best to just stick to....

> I make sure that I'm getting enough of the appropriate minerals and vitamins..

Calcium, magnesium, and vitamin D3, especially. Magnesium deficiency blocks calcium uptake by inhibiting conversion of D3 to the active form, 1-25 vitamin D. And by doing so, magnesium deficiency inhibits magnesium uptake. U.S. data show that more than 50% of all sex/age groups fail to obtain recommended magnesium intake levels, even with supplements included in the data.

Supplementing with mag, cal, and D for a couple of weeks should resensitize the body to permit efficient uptake. However, if deficiency of any of the three is well-established, long-term supplementation is recommended.

> I can't do much weight-bearing exercise due to the old ankle fracture.

Have you considered working out in a swimming pool?

> Have I confused you yet? :-) Pat

No. Keep trying. ;-)

Lar

 

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poster:Larry Hoover thread:866984
URL: http://www.dr-bob.org/babble/20081204/msgs/868164.html