Posted by yxibow on December 9, 2008, at 14:48:00
In reply to Is IT TRUE THAT LUVOX INHIBITS EFFECTS VALIUM, posted by Phillipa on December 9, 2008, at 14:09:01
> Was always under the impression that luvox potentiated effects of valium, xanax wiki says it inhibits them so does that mean less and not more valium with luvox? I seriously need to know. Thanks Phillipa
Luvox is an INHIBITOR at 3A4. That means it inhibits to a degree the breakdown of items that are largely passed through the liver, at 3A4. Valium happens to be one of them, Xanax is even more metabolized there so therefore both SUBSTRATES are held in the body longer than they would normally metabolize and your plasma level is raised, thus you have more of either benzodiazepine in your system.
It's not a extremely strong but a fairly pronounced inhibitor at 3A4, other interactions with other substrates might be more significant and this also depends on chromosomal differences of breakdown among certain races although I don't recall if 3A4 is one of those.
Therefore INHIBITOR doesn't mean inhibiting the effects, it means it traps it in longer and increases anything that binds to that cytochrome.
http://en.wikipedia.org/wiki/P450#Drug_metabolism
-- Jay
poster:yxibow
thread:867740
URL: http://www.dr-bob.org/babble/20081204/msgs/867745.html