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Cymbalta vs. Lyrica

Posted by smart.drug on December 2, 2008, at 10:46:57

Howdy, folks.

As usual, I'm checking in after a long haitus, so an update is in order. To recap, I have Bipolar 2.0 (tm), with possible ADHD and/or a sleep disorder. I have a sleep study coming up, which will hopefully sort things out. First, the list of the happy pills.

Cerefolin NAC, 1 tab with breakfast.
Lovaza 1 gm, 4 times a day with or without food.
Lamictal, 200 mg in the morning.
Provigil, 100-200 mg as needed.
Seroquel 50-150 mg as needed.

For a while, I thought I had found the perfect combination for me. Then, about a week ago, I started to get mild anxiety which became pretty severe when I saw me p-doc at my last appointment. I also complained of fatigue and an all-over aches. By the way, my p-doc and I both agree that benzos are bad, so we won't touch them until all other options are exhuasted. So anyway, she decided to add Cymbalta to my regimen.

She gave me three reasons for trying it:
1, it targets core symptoms, namely depression.
2, it helps with pain and fatigue
3, it treats GAD

When I brought up Lyrica, she gave me the death glare and asked why I brought it up. I said that it can also help with pain/fatigue (approved for fibromyalgia, like Cymbalta) and with GAD. She raised her eyebrows and said that it's used in Europe for that, but it's not approved in America for that. Furthermore, she did not think there was enough evidence.

Okay, so here's the point I'm trying to get to. Can anyone please help me? I have the following questions.

1.) Which of the two medications are superior with respect to generalized anxiety disorder, relative to their benefits versus side-effects?

I have tried Lexapro, a seretogenic drug in the past. It did absolutely nothing for my anxiety (which waxes and wanes.) I have reason to believe that Cymbalta won't work for me either. I realize I might psych myself out, but. I will stick to it, grit my teeth through the side-effects, and titrate upwards to the right dose.

2.) Which of the two is superior with regards to bodily fatigue?

3.) Which of the two is more likely to impact cognitive function, either positively or negatively?

Please provide solid references, if at all possible and where available. Any other interesting tidbits, please feel free to share. Thank you for your time and attention, and I appreciate your advice.


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poster:smart.drug thread:866260
URL: http://www.dr-bob.org/babble/20081123/msgs/866260.html