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Re: Tianeptine and Agomelatine » clipper40

Posted by Marty on November 30, 2008, at 10:33:44

In reply to Re: Tianeptine and Agomelatine » Marty, posted by clipper40 on November 30, 2008, at 8:15:42

Hi Clipper :)

To me, it does somehow but I see the story as more complex than that. We babblers most of the time talk about "levels" of neurotransmitters in term of more or less but very rarely in term of WHERE. As an example, Agomelatine melatoninergic action is mainly in the hypothalamus and is mainly in the frontocortical dopaminergic and adrenergic pathways. WHERE a drug has an effect matters a lot ! Now, Tianeptine doesn't increase serotonin reuptake everywhere in the brain, but only in some specific regions... so trying to figure out what Tianeptine + SSRI does is probably futile for people who aren't neuroscientist. Let's say for the sake of simplicity that the SSRI of that woman
was increasing synaptic serotonin level in every region of her brain. The addition of Tianeptine would in theory (in part) decrease synaptic serotonin level in a 'patchy way'.. in only some regions... now add to that the secondary mechanism of the 2 antidepressant (ex: Tianeptine act on one Adenosine receptor and except for Citalopram all SSRI act directly on other system than the serotonergic one)... figuring out what's the effects of that mix in the brain or the clinical effect a person with X or Y disorder etc is about the neuroscience equivalent of high level theoretical physics mathematic ... :P I don't say that it isn't fun to try figuring out how drug works and interact and learn about of the brain works etc I do like that for some reason. But the more you learn and the more you feel it's most of the time fantasies when we, layman, try to hypothesize in neurology.

I wish we had a neurologist/neuropsychiatrist/neuroscientist coming on the forum from time to time for a little chat on neurology and psychopharmacology. That would be great! but for many reasons isn't very probable .. lol


Sorry Clipper for that babbling of mine, but I feel like sharing that brief moment of lucidity with someone ;)

See ya in 'our own space' ..
/\/\arty

> Hi Marty!
>
> Interesting about that woman. Maybe some of us have been thinking about this wrong. Maybe the serotonin reuptake enhancement from tianeptine is like adding a dopaminergic effect and so you're adding that to an SSRI rather than counteracting it. Does that make any sense?
>
>
>


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poster:Marty thread:855890
URL: http://www.dr-bob.org/babble/20081123/msgs/865889.html