Posted by bleauberry on November 22, 2008, at 18:04:23
In reply to Re: Tell Me All About Parnate » bleauberry, posted by uncouth on November 22, 2008, at 16:33:56
> BLUEberry what is your current regime and why you looking to switch to parnate?
Thank you very much for the detailed post.
As you mentioned effexor+abilify, yeah, though I am not a fan of antipsychotics, I do feel there is some special synergy between an antipsychotic and an antidepressant...though finding the right two is the tricky part. When I added Zyprexa to Prozac many years ago it really changed the way Prozac worked and felt. Lasted a good 8 years.
Chocolate. I love it and eat lots. Don't think I can ever get off nicotine, though I have been at 1/2 pack per day for months now, down from a full pack most of my life. I like the fruit chill nicorette even better, though I still need the cig. Terrible deep dark depression without nicotine. NAC I worry about because it can loosen stored mercury and put it back into circulation, repoisoning, without having the power to fully excrete all that it stirs up. For me, with diagnosed mercury toxicity from amalgam fillings, that is a risky proposition.
Why Parnate? Well, I had an expensive genetic profile test done recently. Took 8 weeks to get the results. They are in. Genes involved with methylation and other stuff are fine. But, of 5 different MAO genes and several COMT genes, they are all in the red, shown as "double mutations". My doc got the results, and so did I, but we haven't met yet to discuss what they mean. It either means my MAO is working overtime and needs to be slowed down (thus Parnate), or it means MAO is not working much, and maybe something like Tianeptine would be better.
Long history of melancholic anhedonic depression, a couple almost-suicides, one hospitalization, a course of ECT, tons of med failures or intolerances. But a good life. Purely biological. Mercury is almost surely the blame, but how to bypass its damage is really a tough mystery to solve. At least now I can see clearly what it did to MAO genes.