Posted by bulldog2 on November 7, 2008, at 18:40:36
In reply to PARNATE POOP-OUT OR NIFEDIPINE INTERFERENCE?, posted by JadeKelly on November 6, 2008, at 17:46:05
> Week and 1/2 with quick great response to Parnate30mg, then subsequent hypertensive crisis. Restart Parnate couple days later with daily Nifedipine 10mg (only way to stop BP spikes). Another week 1/2, now feel worse than before. Any Parnate experts/users,etc. have a couple minutes to answer these questions? Note: had great response on Emsam at 6mg patch for week or so, also, then switched to Parnate.
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> 1. Is parnate known for early response then gone?
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> 2. Do MAOI's just have early stim effect? Thought they ruled that out. Didn't feel like stim.
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> 3. Is it likely just a need for dose adjustment?
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> 4. I know 30mg to be standard for Parnate trial, I'm small and fairly sensitive to drugs too. Is it likely that Nifedipine is whats causing lack of response?
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> 5. Do most people who respond well in 5-7 days on MAOI tend to respond for long time, given right dose?
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> 6. Is it a general rule, that most have to go up in dose to keep original response?
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> Thanks to anyone who can answer these questions for me. I'm getting anxious to figure all this out as I feel lethargic and back to depressed state. See PDoc Monday. Atyp/tr MDD.
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> Thanks All-Jade
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>Could be the Nifedipine. Consider augmenting with a tca as that does give some protection from hypertensive crisis.
poster:bulldog2
thread:861167
URL: http://www.dr-bob.org/babble/20081106/msgs/861353.html