Posted by yxibow on October 14, 2008, at 11:03:43
In reply to Re: Former and Current Nefazodone Users... help, posted by bleauberry on October 13, 2008, at 19:04:38
> The thing that makes serzone unique is the way it blocks certain receptors. The meds that would come closest to doing similar blocking of similar receptors would include zyprexa, remeron, and risperdal. Without a receptor blocker in your mix I doubt you will find anything to replace serzone. Maybe trazodone. It is in the same family as serzone.
Remeron is primarily an a2 drug but yes I believe they in turn form a serotonin blockade at higher doses -- its why I believe Remeron worked for me at a high dose at one point.
Trazodone would take a considerable effort to get used to, and I'm not sure its really safe to have an adult dose of it today.
It can cause priapisms in a small percent (for males, obviously) which must be taken care of post haste -- that doesn't mean everyone will get that.
I have several times but I was on a small dose for sleep so it wasn't an issue really -- umm.. managed to figure a way to take care of it. Anyhow, no its a serious thing.
Also there's the mCPP metabolite issue -- which for a certain few will activate some psychosis.
> I remember you had to get off serzone because the doctor feared liver probs? Cases of that happening were actually quite rare. More common than other meds, but still rare. I don't understand the hesitancy to get back on it.
>Frequent liver tests (monthly) as well as daily supplementation with Milk Thistle should keep you well entrenched in the safety zone.Not sure about the milk thistle, but yes frequent liver tests are basically the protocol with serzone today. The original manufacturer fled. Monthly maybe at the beginning, probably every couple of months or so later on.
Jaundice is very easy to detect, it affects the eyes and a few other parts of the body first and is reversible by stopping the affending agent -- not that I suggest one goes there.
Generic serzone is easily available anywhere in the world either through a doctor or directly through the internet no-prescription pharmacies.
>...but your liver doesn't need any extra care? I mean, what's better of those two choices?The liver, if one is in good health is very regenerative and will return back to a good state, and cirrhosis is something that is not likely to happen. Still, not something worth heading down that path.
Basically if one is on nefazodone I would coordinate with their doctor as to what else can be added safely (and will show up on tests), e.g. ibuprofen, alcohol, etc, and other medications.-- tidings
Jay
poster:yxibow
thread:857074
URL: http://www.dr-bob.org/babble/20081006/msgs/857392.html