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Re: Thyroid levels and Serotonin bulldog2

Posted by Larry Hoover on October 4, 2008, at 17:50:25

In reply to Thyroid levels and Serotonin, posted by bulldog2 on September 27, 2008, at 19:11:43

> T3 (the active thyroid hormone created from T4 in the liver by the 2D6 enzyme) desensitizes presynaptic serotonin autoreceptors


I believe that this source is wrong. T4 is a substrate for cytochrome 3A4, not 2D6. And that's a good thing, because some people have no 2D6 function whatsoever.

3A4 function/rate is influenced by many drugs, and by diet (e.g. the grapefruit effect). Makes you wonder what happens to T3 levels.





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