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data » bulldog2

Posted by azalea on September 25, 2008, at 23:54:54

In reply to amitriptyline + Parnate Less Hypertension, posted by bulldog2 on September 25, 2008, at 8:08:49

Fascinating study. Here's the full reference info:
Title:Will amitriptyline prevent the "cheese" reaction of monoamine-oxidase inhibitors?
Source:The Lancet, Pare yr:1982 vol:2 iss:8291 pg:183-186.

There were 5 patients taking MAOI + different doses of amitriptyline, 2 at 75mg, 2 at 100mg, 1 at 150mg.
Only 1 patient was on tranylcypromine. Other MAOIs were parstelin and phenelzine.

> It's a shame that more docs don't know about this study. Apparently parnate + amitriptyline gives less rise in bp when tyramine is injected.
> Can't find the amount of amitriptyline that they used in this study.
>
>
> > "This is an approximate order of potency. Iproniazid is seldom used now because of the increased risk of hepatotoxicity. Tranylcypromine is the most likely to cause a 'cheese reaction and isocarboxazid the least. An important paper in The lancet, from St. Bartholomew's Hospital, (Pare et al., l982) described the safety and efficacy of combining amitriptyline (Tryptizol) and tranylcypromine (Parnate) - If the patient was on tranylcypromine alone, the rise in blood pressure produced by tyramine1 the dangerous ingredient in cheese, was substantial. The rise in blood pressure was less following a tyramine injection when the patient was on amitriptyline and tranylcypromine. The safety and efficacy of this combination was demonstrated in a controlled trial from the University of Southern California (Raaani et al, 1983) - The other antidepressants investigated at Barts in combination with tranylcypromine were trimipramine (Surmontil) and dothiepin (Prothiaden). They did not confer the same degree of protective effect as amitriptyline


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URL: http://www.dr-bob.org/babble/20080915/msgs/854142.html