Posted by SLS on September 14, 2008, at 15:49:18
In reply to Re: Deplin: Dosage too high?, posted by bulldog2 on September 14, 2008, at 15:40:56
> > > > I hope it works for you. If a lower dosage of Deplin works well for you and does not produce insomnia, I guess we can add insomnia to the dosage-indicator list.
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> > > > - Scott
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> > > I believe that deplin works by converting homocysteine to sam-e. Would it not be cheaper to just purchase sam-e and play around with the dosage? I have found a place where sam-e can be purchased quite reasonably.
> > I don't know if one can say that oral L-methylfolate and S-AMe are clinically equivalent. I found S-AMe to make me dysphoric within hours of taking the first dose. You might be right, though. I guess there is only one way to find out. Remember, though, that Deplin can take 1-2 months to produce reliable results. I am not so familiar with the attributes of S-AMe.
> > - Scott
> Well the makers of deplin have a chart that shows comversion of homocysteine to methione and than to sam-e. However we don't know if l-methylfolate may do other things in the body other than make sam-e. Also the sam-e that deplin helps the body produce may be superior to the sam-e that is maufactured. So deplin is probably a superior product than sam-e pills. However my pharm charges $50 for a bottle of deplin. I will look for a cheaper souce.
If it turns out that your ideal dosage of Deplin is 3.75mg, you can justify its use monetarily.