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Ketamine + SSRI(s)

Posted by Babak on September 5, 2008, at 14:00:21

Hi everyone
I am sure you have all heard about AD effects of Ketamine (best Biopsychiatric site).
I have a progressive and treatment resistant depression. Medication has had limited benefits and is getting less and less effective. I have had numerous ECTs, again with limited benefits which wear out completely over a couple of months. The last thing I have tried is VNS. It has improved my condition substantially otherwise I wouldnt have been able to do this. I was crippled, unable to walk or talk and even think at times. So there it has been a life saver but the improvement has not been to the extent that I can get a job and work which is my goal.
Now I have heard about Ketamine and I am hoping that it would give me enough of a push to break through. So I am desperate to try it but as you know it is not legal and doctors wont prescribe it.
However before I can commit to yet another chemical entering my body I want to know about the risks that I will be taking. The first issue which is of concern to me is its concomitant use with Effexor which is an SSRI and/or SNRI antidepressant. Now I know that SSRIs stop Ecstasy to have much of AD effect and from what I have been reading it seems that Ketamine can be considered of the same family. I have also read about the risks of Serotonin Syndrome, although before knowing about it I have mixed MDMA and SSRI (Seroxat) on many occasions and at very high doses. All I got was a relatively severe head ache.
I take 300mg Effexor and 5mg of Olanzapine. Coming off Effexor is a long and painful affair. But if it prevents Ketamine from having an effect or its full effect, I am prepared to take it once again but I would like to research the facts as much as possible before hand.
Now is there anyone who can contribute to the discussion? I would be most grateful as usual.
Thank you all in advance

P.s. Check out Before VNS it was the only thing which brought me out my immobility. The doctors didnt believe me but if it werent for that stuff I would have died or starved. It is not a miracle cure as they claim on the site but boy o boy it is really fantastic. I used to give a couple to friends who also suffer from depression and they all have become regular clients as am I. My depression unfortunately is in a league of its own in terms of resistant, but Chinese-Formula is helping me on day to day basis more that Effexor or Olanzapine.




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