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Memantine + dextroamphetamine is working for me.

Posted by cumulative on August 30, 2008, at 18:18:07

Like AndrewB, temoigneur, and a few others, memantine as adjunct to my amphetamine has worked well to delay tolerance to the amphetamine's mood-boosting and motivational effects.

I have been using the two together for eight weeks.

I have been doing tremendously well, better than ever, with a great diminishment of my symptoms -- social phobia, anhedonia, loss of motivfation, poor focus, depression, etc.

I can answer questions on this if anyone likes.

It is not a total panacea. I take 40 mg of memantine (30 in the morning, 10 in the evening) and 60mg Vyvanse + 1-2 doses of 5mg dextroamphetamine in the evening. I still notice a little tolerance, although very very little after I added the 10mg evening dose of memantine. Taking one day weekly off works well.

I also take Periactin (cyproheptadine) as a very effective sleep aid.

I have some concerns about a possible loss of cognitive flexibility/creativity and some tendencies towards perseverative behavior with my dextroamphetamine treatment ... I think actually that these are actually less of a problem with nucleus accumbens dopamine release apparently preserved, than they would be without the memantine, but I am considering adding adjunct guanfacine or ... daily low-dose LSD to see if either assists with this.


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