Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Bipolar disorder and genetics. New data. » Marty

Posted by SLS on August 19, 2008, at 12:30:40

In reply to Re: Bipolar disorder and genetics. New data. » SLS, posted by Marty on August 19, 2008, at 11:06:27

> [PS: I know you don't quite fond of my LONGGGG post, but please read this one as I'd like your thoughts about the atypical effects CHELATED(only) Potassium has on me, a Bipolar type 2 and because I think it could interest you because of the potential link with the new study.]

Another interesting observation is that calcium supplement makes me feel considerably worse with an hour. I don't mess around with calcium anymore. Maybe with magnesium? I don't know.

> Wow .. exciting stuff. Personalized/Genetic medecine can't come fast enough! Having more significant target get us closer to this day. Genetic therapy for mental illness has so much potential that if I wouldn't calm myself I think I would cry :P I wish the next step they would take is to find what's promote ANK3 expression and find ways to inhibit those promoters directly rather than indirectly.. reducing the biological events cascade between the drugs mechanism of action target and the reduced ANK3 expression.

I am not familiar with ANK3. However, I do agree with your premise regarding gene therapy being direct rather than indirect via second messenger cascades.

> 1. NaKATPase inhibition: the Potassium would bind to the transporter but would be unable to enter the cell because of the bounded-protein leading to NaKATPase inhibition by way of occupation. That would end up stabilizing the membrane potential.. considering the effect on me this is counter-intuitive and so would implicate other cascading biological events caused by that inhibition.
>
> 2. Enhanced Potassium availability/transport improving, when in depressive state, my defective bipolar neurons ability to fire at will.
>
> 3. Enhanced Potassium availability/transport leading some susceptible bipolar neurons to fire in a random fashion.
>
> 4. Interaction with Potassium ion channels. Antagonism or better 'Agonism' because of the chelation ?


I'm afraid I don't know enough about NaKATPase to be able to comment. I guess I have my next project. :-)


- Scott

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:847161
URL: http://www.dr-bob.org/babble/20080814/msgs/847211.html