Posted by Marty on August 19, 2008, at 11:06:27
In reply to Bipolar disorder and genetics. New data., posted by SLS on August 19, 2008, at 7:14:26
[PS: I know you don't quite fond of my LONGGGG post, but please read this one as I'd like your thoughts about the atypical effects CHELATED(only) Potassium has on me, a Bipolar type 2 and because I think it could interest you because of the potential link with the new study.]
Wow .. exciting stuff. Personalized/Genetic medecine can't come fast enough! Having more significant target get us closer to this day. Genetic therapy for mental illness has so much potential that if I wouldn't calm myself I think I would cry :P I wish the next step they would take is to find what's promote ANK3 expression and find ways to inhibit those promoters directly rather than indirectly.. reducing the biological events cascade between the drugs mechanism of action target and the reduced ANK3 expression.
Btw Scott, did I ever told you how I get QUICKLY excited and my mood improve when I take even low dose of Protein-bounded Potassium supplement ? After I tried about 40 supplements I, in fact, consider Protein-bounded Potassium (with Chromium for 5-HT2 desensitivation/Insulin enhancer) my best discovery. My memory doesn't allow me to remember with confidence even the basics of 'Cell Membrane Potential' right now.. but I may want to revisit this story as Potassium works with Sodium in membrane potential. Interesting fact considering the finding of the new study! Not sure of the implication/mechanism of action at all because ONLY the protein-bounded form as this effect on me ! Possibilities:
PS: I just checked the bottle and I was wrong about the Potassium being protein-bounded: it's in fact bounded to some Peptides, Polypeptides and Amino acids. Even more interesting...
1. NaKATPase inhibition: the Potassium would bind to the transporter but would be unable to enter the cell because of the bounded-protein leading to NaKATPase inhibition by way of occupation. That would end up stabilizing the membrane potential.. considering the effect on me this is counter-intuitive and so would implicate other cascading biological events caused by that inhibition.
2. Enhanced Potassium availability/transport improving, when in depressive state, my defective bipolar neurons ability to fire at will.
3. Enhanced Potassium availability/transport leading some susceptible bipolar neurons to fire in a random fashion.
4. Interaction with Potassium ion channels. Antagonism or better 'Agonism' because of the chelation ?
What do you think Scott ? Any thoughts ? I wish some other Bipolar on the board would give the protein-bounded Potassium a try and report about it. Willing ? The Chelated Potassium is by 'Trophic'.. pretty cheap. Anyone willing to try should stick to this highly available brand for obvious reasons.