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Re: Open letter to Dr.Ken Gillman - Serotonin Synd » yxibow

Posted by Marty on July 30, 2008, at 14:03:01

In reply to Re: Open letter to Dr.Ken Gillman - Serotonin Synd » Marty, posted by yxibow on July 30, 2008, at 12:29:48

> I'm not quite following the one about >cyproheptadine -- it is THE choice in serotonin >syndrome management in hospitals along with >Tylenol and Valium (I think?) for supportive >care. Remember SS is not something you can just >walk around with -- it's pretty deadly if you >have a major episode and not a subclinical one.
---
Hi Jay,

I'm not quite following the one about you not quite following the one about Cyproheptadine... ;) I was just refering to the usual cocktail administred in SS crisis, which include Cyproheptadine for 5-HT2A antagonism, and not suggesting that it could/should be use as I already know that it's almost always part of the cocktail.

The hypothesis is that an acute dose (much more than for depression/anxiety) of Tianeptine added to the usual cocktail could be beneficial. While I'm far from being confident that it would work I think it deserve to be tested in vivo in a lab.

What do you think of the rationale behind this ? Any idea ?

/\/\arty


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