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Re: depressed/irritable in the morning: any ideas plz? » Jay_Bravest_Face

Posted by Marty on July 23, 2008, at 23:46:58

In reply to Re: depressed/irritable in the morning: any ideas plz? » Marty, posted by Jay_Bravest_Face on July 23, 2008, at 22:50:17

> Hi Marty..
Hi Jay

> I think it is an excellent med that is prescribed in way too low doses. 1-2mgs 4x a day seems more what I would like to see be taken. I have been on 2 mg of clonazepam 4x a day for the past 12 years, and I lower my dose when I dont need it, and up when I do need it. I could easily go cold turkey with it, and actually have gone many weeks and even months without it.
---
I agree Xanax is a good drug. I'm currently only taking 0.25mg BID but for me it's already alot as I'm pretty sensitive on benzos. Clonazepam was good for my social anxiety but even at dose as low as .25mg at bedtime it makes me feel depressed in the long run. Withdrawing from 4 years of Clonazepam 0.5mg/day was a nightmare for me and I cant imagine what it would have been if it would have been 2.0mg TID .. just to give you an idea I have weird sensation (sometimes pain) in my face and scalp since I had this withdrawal 2.5 years ago. ... I wish we had Xanax XR in Canada as it would be much better. BTW is the dosage you're talking about for the XR formulation ? I would expect the dosage of the XR formulation to be significantly higher than the old formula.


> I honestly think your Tianeptine may cause some morning problems. Since it dis-inhibits serotonin re-uptake, and serotonin being a part of melatonin, you may not be getting the melatonin you need to feel refreshed.
---
Interesting.. I'll do a research to do if there's any research/link between Tia and Mel. If have some Melatonin but it made me depressed when I gave it a short trial a couple years ago. Maybe it could help but I'll put some more thoughts into it before taking a chance of becoming even more depressed.


> Have you considered a trial of say nefazadone (aka generic Serzone..only available in the U.S. generically)? It does a great job at blocking those 5htp2a and sub receptors that cause many problems with SSRIs (I.E. sexual dysfunction, sleep, loss of affect.)
---
Unfortunately it's not available anymore in Canada since the Serzone removal from the market a couple years ago. That said I'm sure I can find some and I expect it to be cheaper than Tianeptine. If it doesn't cause sexual dysfunction and loss of affect and not too much cognitive impairement it could be a great med for me as I'm a relatively good responder of serotonergic drugs.. it's just that I CAN'T live with their side effects. I forgot about that med.. thanks for remembering me. I'll think about it.

> I am a social worker in a program for autistic kids, and we are finding some amazing results with this med.
---
Really ? I wonder what effects it has on autistic kids. Are they more pro-social ?

> Also, Wellbutrin can easily cause irritability, especially if you are trying to disinhibit serotonin reuptake.
---
Yes no doubt. And I know I'm quite sensitive to this side effect since I tried Parnate a couple years ago... I was raging inside for nothing. It was very difficult for my girlfriend and it almost destroyed our couple in a couple days.

Here's an excerpt of those days:

GirlF.- "Hi sugar! How was your day today ?"
Marty.- "F**k You" -_-

Here's another:

GirlF.- "Please, Could you pass me the butter ?"
Marty.- "F**k You" -_-

.. okay enough :P seriously it was awful but I don't think wellbutrin ALONE depress/irate me in the morning since I took it alone many times. So I think you may be right: It could be Tia+Wel that do this in a synergic way. It would mean a low dose Serzone at bedtime could help a lot with that .... Wel/Serzone/Tianeptine could be it for me since those are the 3 ADs with the LESS side effects of all.

Thanks for your ideas Jay. I usually has a lot of idea and theory but right now I had, for the first time, none.

> What other recent meds have you tried?
---
Alot. Didn't touch the typical TCAs which I suspect would be very bad for me because of the side effects.

A quick sketchy resume would be...
- Every SSRI except for Prozac. Paxil = 4 years
- SNRI Effexor XR (Not interested in Duloxetine)
- Wellbutrin, Tianeptine, Mirtazepine
- MAOI's: Nardil, Parnate, Moclobemide
- Clonazepam, Alprazolam(Xanax), Ativan, Bropazepam and 2 other benzo I can't remember.
- Lamictal, Lyrica, Neurontin, Topomax, Epival and other memory killer that I can't remember of. :S
- Lithium
- Buspar
- Tryptophan, 5-HTP, St-John Worts, Rhodiola, Gaba, bonded Gaba, Theanine, Gotu Cola and many more natural supplements the best being oddly : Chromium and Evening Prim Rose which I continue to take.
- Orap, Risperdal, Seroquel and Zyprexa
- Many ADs Sexual side effect antidotes such as Amantadine, Testosterone, Cyphroheptadine, Yohimbine, supplements and etc.
-Recent quick experimentation: Phenytoin, Vinpocetine, Picamilon, Nootropil... Gerovital is in my desk, but I don't want to touch it since I fear it may make me feel like Moclobemide (BAD).

I'm sure I'm forgetting about ~15-20%..

> Thanks,
> Jay
---
No, Thanks to you.

/\/\arty



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poster:Marty thread:841610
URL: http://www.dr-bob.org/babble/20080718/msgs/841731.html