Posted by linkadge on July 17, 2008, at 11:57:53
In reply to nortriptyline concerns; NE transporter, 5-HT2 Rs, posted by iforgotmypassword on July 17, 2008, at 11:08:20
Wow theres a lot of comments. One thing to keep in mind is that if you can get a medication which exerts more thereaputic effect than side effects, usually one can adapt.
Nortyptaline is a 5-ht2a/c antagonist and this can improve certain forms of executive dysfunction. It may increase OCD like symptoms though, if they are present. Nortryptaline is a serotonin uptake inhibitor, but most people don't get SSRI degree side effects.
You could combat the anticholinergic side effects (should they become problematic) with oral choline, or perhaps a cholinsterase inhibitor like ginkgo.
You may want to continue to look for discussion of geneotoxicity. The studies I read seemed to think nortrpytaline was not genotoxic. The genotoxic TCA's all had some similarity of structural (was it nitrogen? on one of the rings)
Anyhow. I think its fairly safe and worth a shot. Just go up on it slowly.
Linkadge
poster:linkadge
thread:840163
URL: http://www.dr-bob.org/babble/20080706/msgs/840170.html