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Re: Methadone NMDA

Posted by Sigismund on July 8, 2008, at 19:00:54

In reply to Re: Methadone NMDA, posted by bottlecappie on July 8, 2008, at 16:23:29

I wonder if any opiate (given a flattish blood level) will, once dependence is attained, be of very minimal use?

That said, the advantage of bupe as I understand it, is that there is less depression than with methadone and it is not so difficult to get off.

Certainly methadone is strong enough. But what this means in practice with once a day doseage is that you are affected (pain relief) for maybe weeks, and then you arrive at a steady state situation where you feel better for a few hours after your dose and that is it for the day.

More frequent doseage will not make this better. Blood levels will be flatter still, and therefore the incremental improvement will be extremely shortlived after a dose.

Of course there are worse things than being on methadone, like being in terrible pain. But I don't know how much pain relief you can expect long term.

What is the NMDA thing about?




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