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Desipramine vs. Nortriptyline

Posted by fachad on July 6, 2008, at 22:57:27

In reply to Re: Do all TCAs feel like Desipramine? fachad, posted by SLS on July 6, 2008, at 16:47:02

Desipramine is much more potent - in theory - as a noradregenic reuptake blocker.

However, for all the other (i.e. non-target) receptors nortriptyline is much more potent.

So you can expect more sedation, weight gain, dry mouth, constipation, dizziness on standing up, etc from nortriptyline.

Nortriptyline is a much more "dirty" drug, although it is much cleaner than the parent TCA drugs (amitriptyline/Elavil is the parent for nortriptyline and imipramine/Tofranl is the parent for desipramine).

> > No, desipramine is unique. It is a VERY potent noradrenergic drug, and has the FEWEST side effects of any of the TCAs.
> >
> > So it is likely to make you fell racey, but other TCAs are more likely to give you dry mouth, drowsiness, etc.
>
> How would you compare desipramine to nortriptyline?
>
>
> - Scott


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